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09.17.2026

First Patients Dosed in Phase 3 Trial of Linsitinib for Thyroid Eye Disease

Key Takeaways The first patients have been dosed in the global phase 3 ORBIT clinical trial of linsitinib, an oral small molecule inhibitor of the insulin-like growth factor-1 receptor for the treatment of adults with moderate to severe active thyroid eye disease The primary endpoint is the proportion of patients who experience a reduction of at least 2 mm in proptosis in the study eye without corresponding worsening in the fellow eye. Following the 24-week treatment period, patients will be eligible to enroll in a 24-week open-label extension study.

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