CorNeat Vision announced it has completed the preclinical stage of its cornea implant (CorNeat KPro/Keratoprosthesis) and the first synthetic, non-degradable scleral patch (CorNeat EverPatch). The company’s solutions, which also include a glaucoma drainage device, the CorNeat eShunt, will be showcased for the first time at the 37th Congress of the ESCRS (European Society of Cataract and Refractive Surgeons) in Paris, France on September 14th-18th, 2019.
CorNeat’s synthetic biology technology enables its ophthalmic implants to completely and permanently integrate with surrounding tissue. This is done using a synthetic and non-degradable extra cellular matrix (ECM) that provides structural support to surrounding cells and stimulates their growth and proliferation into the implants, according to a company news release. CorNeat Vision’s preclinical trials, which included several animal ocular implantation studies, proved the safety of its technology as it applied to its synthetic cornea (CorNeat KPro), synthetic scleral patch (EverPatch) and glaucoma shunt (eShunt).
At ESCRS, CorNeat Vision will be showcasing the following products:
- CorNeat KPro: A penetrating (full thickness) cornea implant which leverages synthetic biology to integrate a wide aperture synthetic optics within resident ocular tissue. Unlike corneal transplants and previous attempts to develop an artificial solution that are sutured or attempted integration with the native corneal tissue – a tissue that lacks blood vessels and heals very poorly; the CorNeat KPro, following a relatively simple, 30-45 minute implantation, permanently integrates with the eye wall under the conjunctiva, a site that heals much faster allowing firm durable integration. The CorNeat KPro provides an aesthetic, efficient, scalable remedy for millions of people with cornea-related visual impairments and is far superior to any available alternatives. CorNeat KPro is 100% synthetic and its implantation does not require the use of donor cornea tissue.
- CorNeat EverPatch: The CorNeat EverPatch (scleral patch) is the first inert, synthetic and non-degradable tissue substitute for use in ophthalmic surgeries. CorNeat EverPatch replaces the use of human tissue and degradable collagen patches for covering and concealing implants such as glaucoma drainage devices and sealing the eye in cases of missing tissue.
- CorNeat eShunt: The first bio-integrating shunt that leverages non-degradable nanofibers that mimic the trabecular mesh to automatically regulate the intraocular pressure. CorNeat eShunt introduces long term efficacy and avoids clogging by draining deep in the orbit, in the intraconal space.
“We couple innovative ideas and tissue integration capability to create solutions serving to replace damaged biological organs and tissue or repair their function,” Almog Aley-Raz, CorNeat CEO & VP R&D, said in a company news release. “We are excited to have completed the preclinical trial phase with our first two products–the CorNeat KPro and CorNeat EverPatch–and are looking forward to the initiation and successful completion of clinical trials. We invite all interested ophthalmologists and potential business partners to visit the CorNeat Vision booth #D134 at the 37th Congress of ESCRS in Paris to hear about our solutions, view the CorNeat KPro surgery movie which will be presented at the event’s video awards session, and learn more about our successful animal study featured in the Congress’ Poster Village.”