Bayer Acquires Perfuse in $2.45 Billion Deal

Eyetube

Bayer expands ophthalmology pipeline with acquisiton of Perfuse Therapeutics; Viridian announces new phase 3 data for its investigational subcutaneous injection for chronic thyroid eye disease; and Steven Dell, MD discusses the impact of declining reimbursement could on ophthalmic practices. Learn more about your ad choices. Visit megaphone.fm/adchoices

Bayer Acquires Perfuse in $2.45 Billion Deal

Eyetube

Bayer expands ophthalmology pipeline with acquisiton of Perfuse Therapeutics; Viridian announces new phase 3 data for its investigational subcutaneous injection for chronic thyroid eye disease; and Steven Dell, MD discusses the impact of declining reimbursement could on ophthalmic practices. Learn more about your ad choices. Visit megaphone.fm/adchoices

Peripheral Firestorm: The Ischemic Retina

Proliferative disease may still be progressing despite good vision.

Apoorva Jadhav, MBBS, DNB; Unnikrishnan Nair, MS, FRCS, FMRF; and Manoj Soman, DNB, FICO, FRCS

Retina Today

A 62-year-old man with a history of diabetes for the past 10 years presented with complaints of bilateral blurred vision for 2 months with a BCVA of 20/30 OU. Findings on color fundus photography were suggestive of proliferative diabetic retinopathy with fibrovascular proliferation around the optic disc and along the vascular arcades (Figure 1). Widefield OCT demonstrated mild alteration of the foveal contour with minimal parafoveal cystic spaces (Figure 2). The left eye also showed internal limiting membrane folds with vitreomacular adhesion. No significant macular edema was noted. Figure 1 Figure 2 Widefield OCT angiography (OCTA) demonstrated extensive peripheral microvascular alterations consistent with a severe ischemic retinopathy (Figure 3). The most striking feature was the presence of large areas of capillary nonperfusion involving the mid- and far-peripheral retina bilaterally. These regions appeared as well-demarcated flow voids on widefield OCTA, indicating significant capillary dropout and retinal ischemia. At the junction of perfusion and nonperfusion, there were multiple abnormal vascular proliferations visualized as bright, irregular, high-flow networks. These frond-like vascular complexes exhibited disorganized branching and looping patterns, characteristic of neovascularization elsewhere.