Influence of Mediterranean-Style Diet on AMD
Our findings suggest certain dietary and lifestyle habits may confer long-term protective benefits.
Christopher Phung, BA; Beryl Zhou, BS; Robert Luca, BA; and Dimitra Skondra, MD, PhD
Retina Today 
KEY TAKEAWAYS Gut dysbiosis, or an imbalance in the composition of the gut microbiome, has been identified in patients with AMD, pointing toward a potential role of the microbiome in disease progression. In our study, mice were fed three diets: a Mediterranean diet, a Western diet, and a low fat, high fiber mouse diet rich in wheat and corn that is standard for laboratory mice. Compared with the Western diet, the Mediterranean diet was protective against wet AMD and was associated with a decrease in proinflammatory gut bacteria. AMD is a progressive, multifactorial cause of vision loss, especially in Western countries. While early stages may be only mildly symptomatic, advanced AMD, whether geographic atrophy or neovascular disease, can significantly affect a patient’s independence and quality of life. Among the identified risk factors—age, genetics, smoking, race, hypertension, diet—few are readily modifiable, which, given the noncurative nature of currently available therapies, places great emphasis on those that are adjustable. Epidemiological research has demonstrated an association between diet and the risk of AMD development or progression. Diets rich in saturated fats, refined grains, and red meats, reflective of a typical Western diet, are linked to increased AMD risk.1 In contrast, a Mediterranean diet, characterized by high levels of fruits, vegetables, whole grains, and fish, is associated with slower disease progression.2 Despite these findings, a definitive causal link has not been established, and the biological mechanisms underlying this apparent gut-eye connection remain poorly understood. Thus, gut microbiome has gained attention as a promising area of investigation with significant mechanistic and therapeutic implications. The gut microbiome is a complex ecosystem of microbes within the gastrointestinal tract that is heavily influenced by host intake and exerts systemic effects on host immune function and metabolism.