The FDA has authorized initiation of a phase 2 trial of vazegepant (Biohaven, New Haven, CT) for potential treatment of COVID-19 pulmonary complications. Vazegepant is an intranasally delivered calcitonin gene-related peptide (CGRP) inhibitor antagonist in phase 3 trials for the treatment of migraine, according to a report in Practical Neurology.
“Given the unprecedented global threat to life that COVID-19 infection represents, there is an urgent need to test novel approaches to mitigating the consequences of the infection, including reducing the hyper-immune reaction that drives much of the morbidity and mortality in the pulmonary effects of this viral disease,” Vlad Coric, MD, Chief Executive Officer of Biohaven, said. “This pandemic is a call to action for our entire industry. I am grateful to our collaborators at the pulmonary institute at Thomas Jefferson and the team at Biohaven that moved so quickly to develop a clinical protocol and submit this IND to the FDA in the weeks after the pandemic first developed. We owe a debt of gratitude to the scientists at the NIH, FDA, academic centers and pharmaceutical companies who are working hard to study therapies that might battle this terrible disease—the innovative efforts of the true unsung scientific heroes of this crisis will only be fully recognized once better treatments are developed to treat COVID-19.”