05.10.18

Retinal Changes on OCT Angiography May Flag Early Alzheimer’s

Source: Medscape

Microvascular changes in the retina detected by using noninvasive optical coherence tomography (OCT) angiography align well with imaging and biomarker evidence of preclinical Alzheimer’s disease, a new study shows, according to a Medscape report.

The technology detected a significantly larger foveal avascular zone among 14 participants with biomarker-positive positron emission tomography (PET) imaging compared with 16 other people without this preclinical sign of Alzheimer’s (0.30 mm2 vs 0.40 mm2; P = .002).

PET biomarker–positive patients (essentially patients with preclinical Alzheimer’s disease), had “a significantly increased size of the foveal avascular zone. It was robustly positive,” Gregory Van Stavern, MD, a neurologist at Washington University School of Medicine in St. Louis, Missouri, said here at the American Academy of Neurology (AAN) 2018 Annual Meeting.

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