RegeneRx JV Partner Updates on Strategic Dry Eye Discussions


RegeneRx Biopharmaceuticals released a summary of its U.S. joint venture partner, GtreeBNT’s, recent attendance at the American Academy of Ophthalmology meeting (AAO) in San Francisco. The following summary was provided to RegeneRx by GtreeBNT and is posted on Gtree’s web site:

The Gtree team, including CEO Won S. Yang, had numerous meetings regarding its dry eye drug candidate, RGN-259, which is being developed by ReGenTree, LLC (the U.S. joint venture between Gtree and RegeneRx). These meetings took place with several multinational pharmaceutical companies and key U.S. dry eye experts during the AAO meeting held in San Francisco on October 12-15. The meetings went well and most of the meeting participants expressed high interest in the significant clinical results with RGN-259 in the previous ARISE-2 dry eye trial, as well as the potentially strong business opportunities that would be likely if such results are reproduced in ARISE-3 (ReGenTree’s phase 3 dry eye clinical trial). ARISE-3 is progressing smoothly and GtreeBNT will continue discussions with potential strategic partners as the clinical trial moves closer toward completion in the Summer of 2020.

“We are pleased that the AAO meetings were successful and that several multinational pharma companies continue to express a strong interest in RGN-259 as a potential treatment for dry eye syndrome, as well as other corneal-related disorders. As we get closer to completion of ARISE-3, we would expect such talks to intensify and look forward to the successful advancement of our RGN-259 development program and potential returns to our long-standing investors,” J.J. Finkelstein, president and chief executive officer, said in a company news release.

RGN-259 eye drops contain an active small protein, thymosin beta 4, which is naturally occurring in tears and other body fluids. RGN-259 eye drops have demonstrated wide-ranging and multifunctional activities. Such activities underlie the efficacy of RGN-259 eye drops seen to date in alleviating both the signs and symptoms of dry eye. Moreover, RGN-259 eye drops are safe and well-tolerated by patients, and in both ARISE-1 and ARISE-2 patients reported minimal ocular discomfort similar to that of the placebo.


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