Regenerating the Retina; Preventing Clots by Blocking PCSK9; Mimicking the Health Benefits of Exercise

Source: FierceBiotech

Scientists at the NIH’s National Eye Institute have discovered that they can use a transcription factor called Ascl1, combined with a common cancer drug, tamoxifen, to prompt regeneration of damaged retinas in mice, according to a report in FierceBiotech. 

The combo works by activating genes in Müller glia—retinal cells that become neurons. The regenerated cells make functioning connections between neurons and integrate with other retinal cells that send signals to the brain. The approach, published in the journal Nature, could someday be used to treat acute eye injuries and a type of stroke called retinal arterial occlusion, the researchers believe.

Read the full report here.

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