A new animal study suggests affronEYE saffron could help prevent the onset of glaucoma. The antioxidant and anti-inflammatory characteristics of this potent saffron extract, developed by Pharmactive Biotech Products, S.L., demonstrated an ability to protect retinal cells from damage and death and reduce intraocular hypertension — a key aspect of glaucoma development. AffronEYE was an award winner at the 2019 Nutraingredients Asia expo.
The study, published in the International Journal of Molecular Sciences on August 2019, was led by Jose Fernandez-Albarral, PhD, of the Complutense University of Madrid. The study demonstrated the neuroprotective and anti-inflammatory effects of Pharmactive’s proprietary hydrophilic saffron extract (standardized to 3% crocin content) in a mouse model of unilateral, laser-induced ocular hypertension (OHT).
Subjects were comprised of two groups of glaucoma-induced male Swiss albino mice. One group received a single oral daily dose of affronEYE over a period of 7 days; the other group served as a control.
After treatment with AffronEYE, the number of living retinal ganglion cells in the treated group was significantly higher in comparison to the non-treated group. The treated group maintained healthy eye levels by the end of the intervention. Protein biomarkers of inflammation were also reduced.
AffronEYE’s activities are attributed to its naturally occurring bioactive compounds, specifically crocinsand crocetins. These carotenoids are reported to possess a full spectrum of anti-inflammatory, antioxidative, and neuroprotective properties through their ability to scavenge free oxygen radicals, thus reducing retinal cell damage and cellular self-destruction.
“Saffron has been appreciated for its culinary and functional values for centuries and is considered in many traditions as ‘the spice of life’,” Alberto Espinel, head of R&D for Pharmactive, said in a company news release. “AffronEYE is a next-gen ingredient formulated specifically to address eye health. It is extracted from genuine Spanish saffron derived from the delicate dried stigmas of Crocus sativus L. grown in Pharmactive-owned fields in Castilla-La-Mancha in Spain. Our proprietary extraction process allows affronEYE to claim the lowesttherapeutic dose available on the market at 20mg/day and ensures the fastest absorption — faster than other traditional carotenoids.”
Previous studies have also noted the spice’s unique ability to penetrate the blood–brain barrier and reach retinal tissue effectively. “Crocins significantly increase the blood flow in the retina,” Mr. Espinel said. “They are believed to improve oxygenation and nutrient supply to retinal structures, serving to slow or completely prevent the development of glaucoma.”
AffronEYE is all-natural, water-soluble, non-GMO, and has not been irradiated. The ingredient also carries kosher, halal, and organic certifications.