Myelin Oligodendrocyte Glycoprotein IgG Rare in Optic Neuritis

Source: Reuters Health

Autoantibodies to myelin oligodendrocyte glycoprotein (MOG) are rare in patients with typical monocular optic neuritis, according to an analysis of serum from the Optic Neuritis Treatment Trial (ONTT), according to a report in Reuters Health.

In an article online February 22 in JAMA Ophthalmology, Dr. John J. Chen and colleagues at the Mayo Clinic in Rochester, Minnesota, note that since ONTT's inception in 1988 and publication of the last follow-up study in 2008, "novel glial autoantibodies have been discovered that better characterize a subset of patients with inflammatory demyelinating disease, including optic neuritis."

To determine the prevalence of these autoantibodies - to MOG and aquaporin-4 (AQP4) - the researchers analyzed available serum from 177 trial participants at 13 academic referral centers.

Read the full article.

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