Johnson & Johnson Vision will present the first clinical research findings from its comprehensive myopia clinical research program with the Singapore Eye Research Institute (SERI) and Singapore National Eye Centre (SNEC), as well as new data on contact lens and surgical innovations, at the 2020 Association for Research in Vision and Ophthalmology (ARVO) annual meeting. The meeting is being held as a virtual congress with Johnson & Johnson Vision author video presentations published on June 15. Access to Johnson & Johnson Vision accepted studies and author videos can be gained through ARVOLearn.
“Johnson & Johnson Vision is focused on delivering innovation that meets major unmet needs,” Xiao-Yu Song, MD, PhD, Global Head of Research and Development, Johnson & Johnson Vision Care, said in a company news release. “We are excited to present our first research at ARVO 2020 from our unique public-private Myopia strategic partnership that is working to address this growing epidemic. We will also share the latest findings on many investigational technologies, including our drug-eluting contact lenses, extended depth of focus and astigmatism-correcting IOL designs, and our laser cataract surgery operating system.”
BUILDING A BETTER UNDERSTANDING OF MYOPIA
At ARVO 2020, Johnson & Johnson Vision, together with SERI and SNEC, will present the first five studies from the group’s unique public-private strategic partnership. Since the start of the collaboration in April 2019, the group initiated nine research projects that include four clinical cohorts with 631 participants. The research projects are providing real-world evidence to better understand why myopia develops, how it progresses, and how it might be intercepted by investigating underlying mechanisms. Key data presented includes:
- Annual Myopia Progression and Subsequent Year Progression in Singaporean Children. Brennan N et al. This study explored predictors of myopia progression, including whether prior year progression correlates with the year that follows. In the latest findings from the Singapore Cohort Study of the Risk Factors for Myopia, study authors find that prior year annual myopia progression correlates more closely with immediate subsequent year myopia progression. However, it cannot as a single factor fully predict long-term myopia progression. The authors recommend that patients should receive annual check-ups. Factors including age of myopia onset and parental myopia should be considered in determining treatment. (Link to study)
- A Microperimetric Evaluation of Macular Function in Highly Myopic Eyes with Myopic Macular Degeneration. Wong QY et al. Today, it is challenging to get accurate measures of the onset and progression of vision impairment associated with myopia-related pathologies, such as macular degeneration. In this study, investigators explored using microperimetry to measure macular sensitivity and correlate it with axial length; best corrected visual acuity; and the severity of myopic macular degeneration (MMD). They found that macular function as measured by microperimetry may be a more sensitive marker of visual function than visual acuity in eyes with MMD. (Link to study)
DATA ON FIRST-EVER ANTIHISTAMINE-RELEASING CONTACT LENS
Ocular allergy is a pervasive condition that affects up to 20 percent of the US population, with a similar prevalence worldwide.[ii] Allergic conjunctivitis is the most common type of ocular allergy and its primary symptom, itchy eyes, can have a significant impact on contact lens wearers.
Johnson & Johnson Vision is working to address this major unmet need through the development of the investigational antihistamine-releasing contact lens (etafilcon A with 0.019 mg ketotifen). Research published at ARVO 2020 shares new data on the lens’s drug release and clinical efficacy over time:
- The Ex Vivo Drug Amount and Clinical Efficacy of an Antihistamine Releasing Contact Lens Over Time. Pall B. In this study, Johnson & Johnson Vision ketotifen containing investigational lenses exhibited a consistent release of the antihistamine during the wear-period. Approximately 80% of the drug present in the lenses was released every hour based on what was remaining in the lens over a 5-hour period. This release profile was consistent with the 15-minute onset, and 12-hour duration of action efficacy results from previous studies. (Link to study)
EXTENDED DEPTH OF FOCUS LENS INNOVATION
Cataract patients’ preference for presbyopia-correcting IOLs (PCIOLs) can vary based on individual lifestyle needs, and Johnson & Johnson Vision is advancing programs to ensure the broadest range offerings and highest performance. Extended depth of focus (EDOF) technology was pioneered by Johnson & Johnson Vision in 2016 to provide patients with a PCIOL with better continuous range of vision and image quality compared to multifocal lenses. Since the first EDOF lens, Tecnis Symfony, was introduced, Johnson & Johnson Vision has continued to innovate EDOF technology. Research published at ARVO 2020 shares new data on Johnson & Johnson Vision EDOF designs:
- Optical and Predicted Visual Performance of Multifocal and Extended Depth of Focus Designs. State M. In this study, authors compared Johnson & Johnson Vision EDOF designs with multifocal lenses and found that the latest EDOF IOL lens in the Symfony Plus IOL family provided superior distance and intermediate image quality, while maintaining comparable near vision. (Link to study)
ASTIGMATISM MANAGEMENT SOLUTIONS
Astigmatism reduces distance and near visual acuity, vision quality, and depth perception. In the US, 38% of patients with cataracts have moderate to severe astigmatism (≥ 1.00 D)[iii]. Yet astigmatism is corrected in less than half of patients at the time of cataract surgery, due to limitations in currently available astigmatism treatment modality and toric IOL technology. Even subtle shifts off the target IOL placement can impact a patient’s outcome, so surgeons need astigmatism solutions that help ensure accurate astigmatism assessment and IOL placement. (Link to study)
- Automatic cyclorotation measurement with a femtosecond cataract laser. Dewey D et al. In this study of Catalys cOS 6.0 with advanced astigmatism management, a new software for the Catalys Precision Laser System, preop image pairs were collected from a Cassini topographer, and Catalys Precision Laser for patients who underwent cataract surgery at two clinical sites. The image pairs were graded for cyclorotation between the preop and docked conditions by 3 different graders aided by an image-based computer grading tool. Data showed Catalys automatic cyclorotation measurement and image guided iris registration can be registered to preop Cassini images in 94% of eyes with an accuracy of better than 2 degrees. (Link to study)
Key Johnson & Johnson Vision Scientific Abstracts At ARVO Annual Meeting 2020:
Myopia: SERI – J&J Vision Joint Research
- Annual Myopia Progression and Subsequent Year Progression in Singaporean Children. Brennan N et al.
- A Microperimetric Evaluation of Macular Function in Highly Myopic Eyes with Myopic Macular Degeneration. Wong QY, Singapore Eye Research Institute.
- Axial length/corneal radius of curvature ratio (AL/CR) in children on atropine eye drops. Chia A.
- Influence of Greater Axial Length on Prevalence of Myopic Maculopathy in Cohort of Highly Myopic Eyes. Yu DJG, Singapore Eye Research Institute.
- Comparison of Refractive Changes in Myopia Progression in Guinea Pig Myopic Models. Jiang L, Singapore Eye Research Institute; Kathrani B et al.
- Evaluating On-Eye Wavefront Aberrations of a Soft Contact Lens with an Optical Design Simulating Orthokeratology. Cheng X.
- The Ex Vivo Drug Amount and Clinical Efficacy of an Antihistamine Releasing Contact Lens Over Time. Pall B.
- Optical and Predicted Visual Performance of Multifocal and Extended Depth of Focus Designs. State M.
- Effect of Blocking Violet Light in Extended Depth of Focus Intraocular Lenses. Faria-Ribeir M.
- Trend in Glistening Density in Acrylic Inraocular Lenses and Its Relation to Stray Light Performance. van der Mooren M.
- Effect of Pupil Size on Optical and Visual Performance of Monofocal IOLS. Koopman B.
- Contrast Sensitivity Safety Limits for IOLS – Risk of False Negative and False Positive Conclusions. Rosen R.
- Evaluation of the Rotational Stability of Four Prototype Toric IOL Haptic Designs. Straker B.
- Light Intensity Distribution of Diffractive Ophthalmic Lenses. Weeber H.
Cataract & Refractive
- Automatic cyclorotation measurement with a femtosecond cataract laser. Dewey D.
- Methods and Design to Reduce Cyclotorsion and Decentration Error for Corneal Lenticule Extraction Surgery with a Next-Generation Femtosecond Laser System. Voorhees A.
- Comparison of flap and iLex induced light scattering at retina between new and on market femtosecond lasers. Bing L.
- Evaluating the accuracy of refractive lenticule created by a new femtosecond laser in glass. Chen L.
[i] Holden et al. Ophthalmology. 2016.
[ii] Pall et al. Cornea. 2019
[iii] Hill WE. Prevalence of corneal astigmatism prior to cataract surgery. 2019. Available at: https://www.doctor-hill.com/iol-main/astigmatism_chart.htm