Gene Mutation Found in Aqueous Humor May Detect Vitreoretinal Lymphoma

Source: Reuters Health

Ultrasensitive droplet digital polymerase chain reaction (ddPCR) is a potential new biopsy tool to diagnose and monitor vitreoretinal lymphoma (VRL), new research from the Netherlands suggests, according to a report in Reuters Health.

Aqueous humor paracentesis can detect MYD88 L265P gene mutations in the aqueous humor (AH) of patients with vitreoretinal lymphoma and is relatively less invasive and safer than taking vitreous fluid (VF) specimens, the authors write in JAMA Ophthalmology, online July 19.

“This approach may provide a valuable additional tool for minimally invasive liquid biopsy analysis of patients suspected of having VRL,” they write. “As molecular techniques are evolving rapidly, this may enable the role of AH analysis in routine diagnostic workup of patients who are presenting with a differential diagnosis, including VRL.”

Read the full article.

Recent Content