Cyclosporine Emulsion Promising in Vernal Keratoconjunctivitis

Source: Reuters

Cyclosporine A cationic emulsion (CsA CE) appears more effective than vehicle alone in treating pediatric patients with vernal keratoconjunctivitis, according to a study funded by the developer, Santen, as reported by Reuters.

In a paper online December 16 in Ophthalmology, Dr. Dominique Bremond-Gignac of Paris V Descartes University, in France, and colleagues note that this potentially debilitating orphan disease more commonly affect boys than girls and is managed using off-label treatments. A Santen CsA emulsion is approved in Europe for severe keratitis in adults with dry eye disease.

To investigate whether the agent might also provide effective therapy for vernal keratoconjunctivitis, 169 children and adolescents with a mean age of about 9 years – about 80% of whom were boys – were randomized to treatment with the emulsion or to vehicle alone.

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